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In lactating cows, hindgut microbial-mediated secondary BAs metabolism was closely associated with plasma glucose and BHBA levels, mainly through remodeling taurine-conjugated and deconjugated BAs profiles to influence lipid absorption, suggesting the hindgut microbiotaBAs axis is critical for adapting to periparturient negative energy balance 85

6) Muscle and Joint Pain Joint hypermobility syndrome is a genetic disorder that affects the joints and causes pain and exhaustion