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Removing electronic devices from the bedroom reduces both light exposure and psychological associations with wakefulness

The mRNA levels of multiple enzymes involved in the biosynthesis pathway using mitochondrial iron (heme and ironsulfur clusters) are downregulated

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Meanwhile, gut microbiota dysbiosis also had strong influence on OA development through the gut-joint axis: intestinal barrier disruption, increased endotoxemia throughout the body, and decreased SCFA all drove joint degeneration