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Abrupt treatment withdrawal, even in the absence of systemic symptoms or laboratory alterations, can lead to DRESS recurrence.17,75 In cases with minimal systemic symptoms, symptomatic therapy and medium-potency topical corticosteroids can be used.76 Conditions refractory to corticosteroid therapy can be treated with intravenous pulse therapy with methylprednisolone (1 g/d, for three consecutive days)