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Researchers have noted that the two peptides appear to work through distinct but synergistic pathways
doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois
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However, the oral route cannot be excluded as it did not depend on intrinsic factors only, as the simple diffusion (without the need for intrinsic factors) is now considered another mechanism for the absorption of vitamin B12 [49, 50]
MOTS-c converges on AMPK, the cells energy sensor, and under metabolic stress relocates to the nucleus to help regulate gene expression [4]
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