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Current evidence suggests the individual peptides are generally well tolerated when used appropriately, but long-term human data on the full KLOW stack is still limited

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At the same time, a low plasma vitamin C level is often associated with low levels of antioxidant enzymes, such as SOD and glutathione peroxidase (GPx) [211], and these levels decrease in the BALF shortly after exposure to irritants [277]

Notably, in EAU mice, an increase in BRB permeability was observed, as evidenced by widespread Evans blue staining leakage in retinal vessels (105, 106)