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In this report we demonstrate for the first time the preferential targeting of P-gp-expressing MDR cells (CHO R C5 and MDA-Doxo 400 ), relative to drug sensitive P-gp-negative cells (AuxB1 and MDA-MB-231), with clinically achievable concentrations of tamoxifen [21]

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demonstrated that in dendritic cells (DCs), LPS-induced glycolysis is repurposed to replenish citrate, an intermediate metabolite in the TCA cycle that is depleted for the de novo synthesis of fatty acids ( 2 ( de novo lipogenesis is important for phagocytosis as it requires ongoing lipid synthesis in the ER for membrane expansion, such that Ms can surround and capture targeted pathogens for internalization ( de novo lipogenesis, an anabolic process that is NADPH-dependent, in regulating the inflammatory response of myeloid cells

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