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Nevertheless, the selection of the enzyme is crucial to the adoption of this approach

Invest 103 , 253259 (1999)

Importantly, the activity of GSK3 is suppressed at the leading edge of migrating cells, which allows these MAPs to bind and stabilize microtubules at the cell cortex [56]

As the name implies, antioxidants are substances that are capable of counteracting damaging effects on the body

However, they may be more likely to discontinue their ICI due to an irAE, or be at higher risk of an irAE specific to their condition (for example, colitis in a patient with a history of IBD)