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Uchida, T

H.ZhangX.TangX.PuH.et al (2020)

While both diets were low in calories and fat, only the low-GI diet improved overall insulin sensitivity, fibrinogen levels (an inflammatory protein), and menstrual regularity, highlighting its superior metabolic benefits

Rats have many physiological and anatomical similarities to humans

Possible Direct Mechanisms Although indirect effects dominate, GLP-1 receptors are expressed in reproductive tissues, suggesting potential direct roles: Ovarian Effects: Animal studies demonstrate GLP-1 receptor activation can influence granulosa cell function, increase cyclic adenosine monophosphate (cAMP), and modulate steroidogenesis