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This intricate interplay between metabolism, apoptosis, and fibrosis has been validated in single-cell sequencing studies, in which the spatiotemporal dialog between parenchymal and non-parenchymal cells constitutes the molecular basis of disease progression 54,55

Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy

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By observing serum insulin secretion and blood glucose concentration in rats, it was found that L-theanine downregulated the expression of SGLT3 and GLUT5 in the intestinal tract, leading to the inhibition of glucose uptake in the small intestine (78)