This therapy can be beneficial for patients who are unable to obtain sufficient amounts of this nutrient through dietary sources or oral supplements
Notably, redox signaling events are significant regulators of cell death pathways, among which GSH depletion has been demonstrated to be a vital early hallmark in the progression of different cell death mechanisms [18]
Additionally, a growing number of emerging and re-emerging fungal pathogens, such as species of Fusarium , Mucorales , Histoplasma capsulatum , and Sporothrix , pose significant threats to immunocompromised populations
Examination of the GCL from these different organisms suggests that the interplay between the redox-sensitive thiol-switch and dimerization of the plant enzymes occurred later in evolution and may be related to compartmentalization of glutathione synthesis in the chloroplast (Gromes et al., The sub-organellar localization of GCL raises questions about redox regulation of glutathione biosynthesis in plants
doi: 10.4161/cbt.4.10.2184 127 LiHJiaYWangY
