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In IC + OB rats on day 3, immediately after removing the additional colon obstruction and the obstructing ring, grossly large pale flat areas without mucosal folds occupying the entire ligated segment and failed vascular presentation appeared (Table 3, Figures 17 and 20-22), with even more pronounced severe edema of the lamina propria and continuous diffuse edema of the submucosa as well as pronounced dilatation and stasis of the submucosal blood vessels

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Understanding potential concerns enables informed decision-making and appropriate monitoring