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The mechanistic hypothesis is elegant: BPC-157 initiates the early phase: local vasodilation, angiogenesis, growth factor expression, terrain preparation TB-500 takes over: mobilizes stem and progenitor cells, directs migration via G-actin, sculpts matrix remodeling Both peptides operate on complementary temporal scales (BPC early, TB later) and on distinct cellular targets (endothelium and growth factors for one, migratory cells for the other)

Li H, Shi Y, Wang X, Li P, Zhang S, Wu T, et al

974-977 Esposito, P., et al., 2003

Senescent cancer cells as vaccine therapy Therapy-induced senescence is associated with anticancer treatment and promotes deleterious effects such as relapse, drug resistance or immunosuppression 71

Friedman SD, Baker LD, Borson S, Jensen JE, Barsness S, Craft S, et al