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297,298,299 However, ertugliflozin in the VERTIS trial did not show superiority to the placebo in T2D patients with established ASCVD

After absorption into enterocytes, soluble curcumin and its metabolites face two potential pathways: efflux back into the intestinal lumen via transporters, such as MRP2, BCRP, and P-gp, or movement into the portal blood through MRP1 and MRP3 transporters (92, 121)

10.7554/eLife.85862 101

Based on this pharmacokinetic profile, administration of cagrilintide to participants with varying degrees of renal or hepatic impairment is expected to yield comparable exposure across dose levels and dosing frequencies, without compromising safety