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Excess reducing equivalents, for example, may impair sperm production by inhibiting the physiological ROS-mediated signaling essential for meiosis and spermiogenesis [31]

For example, AuNC-Pt could be fabricated by conjugating the Pt(IV) prodrug to the amine group on the surface of AuNCs and proved to be effective in limiting Pt toxicity while effectively maximizing chemotherapeutic efficacy via depleting intracellular GSH (Yang et al., 2020) (Figure 2C)

PMID: 36170435

A study in a mouse model of AD assessed the effects of axitinib on cognitive abilities and memory (Yuan, et al