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By the second week of the study both groups showed an improvement in their symptoms a two-point improvement in the disability scale used (Guys neurological disability scale or GNDS) a wider assessment of disability than the more often used EDSS (Expanded Disability Status Scale)

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Clinical signs of B12 deficiency include nausea, vomiting, loss of appetite, poor absorption of food (malabsorption syndrome), constipation, gas, weight loss, fatigue, lethargy, abdominal pain, and diarrhea