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Regarding the role of MMP-2 and MMP-9 in RA, these gelatinases, typically expressed at low levels, increase in pathological conditions, driving synovial fibroblast-mediated inflammation and cartilage degradation by enhancing production of IL-1, IL-6, IL-8, and TNF- via activation of NF-B, extracellular signal-regulated kinase, and c-Jun NH2-terminal kinases (71, 72)

Individual plots were created for each dataset and include the reference genome and coverage statistics

D.ShinJ

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Hepatocyte ballooning was classified as 0 (none), 1 (few), or 2 (many cells/prominent ballooning)