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Antibody drug conjugates for treatment of breast cancer: novel targets and diverse approaches in ADC design

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This is seen for GRK2 and GRK3 particularly with G q -coupled receptors, where the kinase binds to the GPCR and also to G q via the N-terminal regulator of G protein signalling-like region of the GRK, so preventing coupling between GPCR and G protein (Ferguson, 2007)

Carboni I, De Felice C, De Simoni I, Soda R, Chimenti S

Microbiol Infect Dis