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TNS4 expression is transcriptionally regulated by MAP kinase signaling pathway and plays a critical role in tumorigenesis in several tissues including the colon

Because NNMT activity intersects methyl donor utilization and nicotinamide handling, experimental inhibition can be used to probe pathway level relationships among methyl economy balance, NAD+ salvage flux, and downstream metabolic signaling in a range of preclinical systems

The most quantitatively striking effect reported in the Dihexa literature is on dendritic spine density in rat hippocampal neuron cultures

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Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse