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It is not approved for medical uses outside of Russia

For acute pain crises, cortisone may still be the pragmatic choice

Microsomal prostaglandin E 2 synthase-1 (MPGES-1), a member of the MAPEG family, is implicated in the biosynthesis of prostaglandin E 2 a metabolite of arachidonic acidinvolved in several biological functions

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Because of this short half-life, clinical experts often recommend splitting the daily dose (e.g., taking half in the morning and half in the evening) to maintain steady, round-the-clock antioxidant levels in the bloodstream