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524 In the advanced stages of atherosclerotic disease, macrophages destroy the collagen of the fibrous cap and induce smooth muscle cell death by secreting multiple types of inflammatory factors and matrix metalloproteinases (MMPs), thus exacerbating plaque instability

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doi: 10.1093/ndt/gft465 63 GurevichFPerazellaMA

Currently in Phase 3 clinical trials under Eli Lilly, retatrutide is not FDA-approved and cannot be prescribed through standard pharmacies

discard after 30 days or if cloudy