Subsequently, JAKs phosphorylated Insulin receptor substrate 1 (IRS1) and 2 (IRS2) which evoked signaling through the PI3K/AKT pathway (Fig
Comprising the subunits solute carrier family seven member 11 (SLC7A11) and solute carrier family three member 2 (SLC3A2), System Xc is a vital antioxidant System, facilitating the 1:1 exchange of cystine and glutamate across the cell membrane (Yang and Stockwell, 2016
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Development of novel therapeutics targeting mitochondrial metabolism In recent years, an increasing number of mitochondria-targeted therapeutic candidates have entered preclinical development or clinical evaluation, showing promising anti-CRC potential [146] (Table 1)