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In some embodiments, the poloxamer is P407

When metabolic stress hits the cell (low energy, high oxidative load, glucose imbalance), MOTS-c is released from the mitochondria, enters the cytoplasm, and ultimately translocates into the cell nucleus where it regulates expression of stress-adaptation genes

doi: 10.1371/journal.pone.0015004 129 LiYTamWWYuYZhuoZXueZTsangCet al

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13 Laboratory testing can also establish the presence of hyperandrogenism, and assessment of cardiometabolic risk, through both blood tests and medical history, is recommended