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If discomfort occurs, reducing frequency or seeking professional advice may help

Nerve damage involves inflammation, vascular compromise, neurotrophic factor deficiency, oxidative stress, and mitochondrial dysfunction

Some of the most promising available treatments for the melasma are: elimination of causative factors, protection from UV radiations (with sunscreen application), and use of triple combination (hydroquinone, tretinoin, fluocinolone)

A split schedule can be used when the goal is to distribute signaling opportunities rather than concentrate all exposure into a single administration window

[DOI] [PubMed] [Google Scholar] 11.Sikiric P, Seiwerth S, Brcic L, Sever M, Klicek R, Radic B, et al