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Senescent microglia may have a reduced capacity to modulate neuronal activity because of genetic changes that result in reduced surveillance, migration, and sensitivity to endogenous ligands, and a heightened sensitivity to pathogens, as seen in 24-month-old mice (Hickman et al., 2013

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Compared with IL12 mRNA-loaded liposomes, aerosolized exosomes demonstrated better mucus penetration 214,215 , resulting in notable immunogenicity

Notably, iron overload, ROS accumulation, abnormal ferroptosis, and inefficient erythropoiesis are all hallmarks of -thalassemia [180]

A licensed provider can help determine which is appropriate for you during your consultation