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These tau-related changes further disrupt neuronal cytoskeletal integrity and intracellular transport, leading to synaptic dysfunction and neuronal death ( Figure 2 )

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Fast Facts See the current Solicitation dates DOD is a contracting agency Component initiated topic-driven projects - Army United States Army- Navy United States Navy- Air Force United States Air Force- CBD Chemical and Biological Defense- DARPA Defense Advanced Research Projects Agency- DHA Defense Health Agency- DLA Defense Logistics Agency- DMEA Defense Microelectronics Activity- DTRA Defense Threat Reduction Agency- MDA Missile Defense Agency- NGA National Geospatial-Intelligence Agency- OSD Office of the Secretary of Defense- USSOCOM United States Special Operations Command Offers both SBIR and STTR programs Fund $2.3 Billion in SBIR/STTR topics Three scheduled Broad Agency Announcements (BAA) as well as a As Needed BAA Proposals only accepted in response to a BAA topic DOD has 2 types of topics (Specific/Focused and Open Topics)