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The significance of the role of TBC1D4 in insulin function was demonstrated when a loss-of-function mutation was identified as the cause of severe isolated postprandial hyperinsulinemia

doi: 10.1191/096032700674230830

Derendorf H, Meibohm B (1999) Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives

These effects are downstream of better sleep and improved metabolic function rather than a direct neurological effect of the peptide, which makes them durable rather than temporary