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Saudi J Biol Sci 23(1):S16S21 Gururaj AE et al (2002) Molecular mechanisms of anti-angiogenic effect of curcumin

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Substantial evidence has shown that renal fibrosis is linked to hyperactive pro-fibrotic molecular players, such as the renin-angiotensin system (RAS), reactive oxygen species (ROS), Toll-like receptor 4 (TLR4), and aryl hydrocarbon receptor (AHR) [22-25]

The tight junctions (TJs) between these cells are the real MVPszipping your gut lining together to prevent anything unwanted from slipping through