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Their ability to mimic or inhibit specific protein functions makes them valuable tools in laboratories exploring both fundamental biology and experimental therapeutics

Irregularly contracted erythrocytes (eccentrocytes with hemoglobin puddled to one side of the RBC) and bite cells are seen in the Wright-stained peripheral blood smear

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While SESN2 and p21 expression by Nrf2 represents potentiating feedback, the regulation of MDM2 expression contributes to favouring p53 turnover thus restoring p53 low levels