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CJC-1295 is a GHRH analog that stimulates the GHRH receptors, while ipamorelin activates the ghrelin receptors throughout the body, increasing GH levels but also stimulating appetite and peristalsis

The underlying mechanism involves AS-IVs ability to reduce mitochondrial ROS in myocardial cells of MI mice, inhibit NLRP3 inflammasome activation, and subsequently downregulate the expression of downstream inflammatory factors such as IL-18 and IL-1, along with the caspase-1 regulator involved in cell pyroptosis

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