This could be the mechanism by which XO inhibitors provide protective effects in ischemia/reperfusion-related conditions (Khatib et al., 2001)
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Glutathione is the liver's primary tool for neutralizing toxins, so providing it in a liposomal form can help maintain the liver's protective capacity
Future studies could focus on elucidating the specific mechanisms by which PHGDH regulates immune responses within the TME, thereby developing more effective combination therapeutic strategies
To date, 14 studies have investigated GSH, GSSG, GSH/GSSG and/or tGSH levels in the plasma of healthy adults (Andriollo-Sanchez et al., 2005, Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Kretzschmar et al., 1991, Maciejczyk et al., 2019, Michelet et al., 1995, Nuttall et al., 1998, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), with the majority using HPLC (N = 10, 71%) (Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Michelet et al., 1995, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), and the remaining using colorimetry (N = 2, 14%) (Kretzschmar et al., 1991, Maciejczyk et al., 2019), enzyme-rate essay (Nuttall et al., 1998) (N = 1, 7%), and spectrophotometry (N = 1, 7%) (Andriollo-Sanchez et al., 2005) (Table 3)
