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Elevated ROS formation in the vessel wall is a key feature of cardiovascular disease and contributes to endothelial dysfunction, vascular inflammation, and cardiovascular remodeling (6)

If even 0.010.1% dissociates locally ~2.525 M free Cu translates into ~5085% inhibition of 5AR1

645 Transcriptome sequencing of neuropathic pain mice showed that TRIM28 is a crucial regulator of ferroptosis, and TRIM28 regulates iron homeostasis and ferroptosis in spinal microglia by downregulating GSK3 expression and regulating autophagy

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Evidence from patients with epilepsy showed that epileptic tissues had significant BBB abnormalities (64) and showed a more significant tendency to hemochemistry than normal tissues (69)