Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway
The 1-MX dose administered to the rats was calculated using US Food and Drug Administration for human equivalence doses (HED), assuming a human weight of 60 kg [31]
1 Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age, with a global prevalence ranging from 11% to 13% based on the Rotterdam diagnostic criteria ( Growing evidence suggests that the gut microbiome plays a fundamental role in maintaining host metabolic, immune, and endocrine homeostasis ( Building upon these pathophysiological insights, recent clinical investigations have identified distinct gut microbial signatures in PCOS patients, characterized by reduced -diversity and specific taxonomic alterations that correlate with key clinical features ( 2 The gut-ovary axis The gut microbiota and ovaries engage in sophisticated bidirectional crosstalk through an integrated network of metabolic, immunologic, and neuroendocrine pathways
6.5 Endometrial cancer Obesity is a significant risk factor for endometrial cancer in women
2012 Modulates 4,000+ genes including DNA repair, antioxidant defense, and anti-inflammatory pathways toward healthier expression patterns