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Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake

A visible sign of protein denaturation that reduces bioavailability by 1525% according to stability studies in Pharmaceutical Research

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Several clinicians working with investigational peptides report that AOD 9604 appears most effective when the patient is already in a mild caloric deficit and performing regular exercise, as the free fatty acids liberated by the lipolytic process need to be oxidized, not re-stored