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1 2 "Glutamate receptors in neuroinflammatory demyelinating disease"

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By decreasing ROS production and inactivating the NF-B pathway, P4HB knockout inhibits the inflammatory responses of macrophages, including migration, M1 polarization, and secretion of TNF- and IL-6 [37]

Leyden J, Stephens T, Finkey M, Appa Y, Barkovic S

Estrogen can also impact mitochondrial biogenesis, function, and regulation of ATP production.[ref] In a nutshell, estrogen causes the body to increase the production of other hormones, growth factors, and metabolic factors