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10.1073/pnas.1502285112 71 ZhangX.LinY.XinJ.ZhangY.YangK.LuoY.et al (2024)

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As AD progresses into the chronic phase, Th1-mediated immune responses become increasingly dominant, characterized by the sustained overexpression of IFN--induced chemokines such as CXCL9, CXCL10, and CXCL11

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SCFAs produced by bacterial fermentation of dietary fiber stimulate colonic cells to secrete peptide YY and GLP-1, which signal the brain to regulate appetite and insulin sensitivity [44]