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Conclusion IGF-1 LR3 is a synthetic analogue of natural human insulin-like growth factor 1

On the basis of a range of biochemical and thermodynamic arguments, Williams (1982) suggested that the oxidation state of cytosolic iron is iron(II) and that its concentration falls in the range 10 7 10 6 M, a proposal supported by fluorescence studies (Breuer et al 1995)

Inflammopharmacology, 7(1), 114

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8 Antioxidant defenses are not completely efficient, and increased free-radical formation (oxidative stress) is likely to increase the damage