In an open uncontrolled trial in 20 men with idiopathic infertility and a low testosterone-to-estrogen ratio, three months of treatment with letrozole resulted in improved sperm motility and morphology, reduced sperm DNA fragmentation, increased testosterone-to-estrogen ratio, and four spontaneous pregnancies
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Stable, oral glutathione for vital support
Clinical manifestations can include acne, excessive body hair (caused by high androgen male hormone levels), irregular periods and infertility (due to infrequent or irregular ovulation), and metabolic issues, such as insulin resistance and metabolic syndrome, causing difficulties with weight management