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The researchers developed a strain of mice that totally lacked this gene in order to study what happens when its missing

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Factors include: pH of gastrointestinal fluids Rate of gastric emptying and intestinal motility Presence or absence of food (which can enhance, delay, or reduce absorption), and Patient's age Disease states such as malabsorption syndromes (e.g., Crohn's disease) or liver disease can also profoundly affect bioavailability