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2.5.2 Covariate model The influence of potential covariates on tacrolimus PK variability, including age, sex, height, body weight (WT), fat-free mass, grafted hepatic weight, hematocrit (HCT), albumin (ALB), aspartate aminotransferase (AST), total serum bilirubin (TBIL), creatinine clearance, POD, concomitant medications, and CYP3A5*3, CYPP3A4*1G, SUMO4, and NR112 genetic polymorphisms in both donors and recipients, was investigated

Dauge V, Philippe C, Mariadassou M, Rue O, Martin JC, Rossignol MN, et al

Both variables are influenced by food intake and circadian rhythms

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Sin embargo, actualmente no hay estudios similares de este tipo realizados en humanos