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Only studies involving adults ( 18 years) were included to avoid the heterogeneity introduced by juvenile or atypical Parkinsonian syndromes, which may differ in aetiology, progression, and treatment response

PINK1 then dimerizes and undergoes autophosphorylation, forming a signaling platform that phosphorylates both ubiquitin and the cytosolic E3 ubiquitin ligase Parkin

Is it better to keep them in separate vials or combine them