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Spermatozoa are particularly susceptible to increased ROS levels because their membranes contain more polyunsaturated fatty acids, which are extremely sensitive to peroxide reactions

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Since most PK-deficient patients are compound heterozygous for two different mutations, rather than homozygous for one, several different tetrameric forms of PK-R may be present, each with distinct structural and kinetic properties

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Hypobaric hypoxic experiments are performed in especial chambers (simulation/decompression chamber) and rats can be easily placed in large number at one time due to small in size