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In C3H/HeJ mice, intravenous MSC administration significantly reduced serum levels of key inflammatory mediators, including IFN-, CXCL9, and CXCL10 [48]

doi: 10.1016/j.fertnstert.2017.01.001 5

278,279 In addition, this technology is used in the clinically approved vaccines ALC-0315 (BNT162b2-Comirnaty) and SM-102 (mRNA-1273-Spikevax), where the pKa value ranges from 6.1 to 6.7