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These may include digestive and nervous signs, such as: Hypersalivation Vomiting Diarrhea Agitation, followed by depression Muscle tremors Incoordination (wobbly walking) Seizures Rapid breathing Bluish gums Dilated pupils Rapid heart rate High blood pressure Cardiac arrest In severe poisoning, dogs' skeletal muscles can paralyze, which will cause respiratory arrest and death

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His son and grandson, both named Joseph, carried on his vision until the mid-19th century when his four great-grandsons incorporated the business into Mappin Brothers Ltd