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Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]

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v) regardless of the presence or absence of dyslipidemia, the oxidative stress status, highlighted by the decrease of GPx, triggers lipid oxidation, with the formation of anti-LDL-oxidized antibodies, leading to the onset of vascular endothelial aggression, with early atherogenic pathology

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