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Synonyms: 5-Amino-1MQ, NNMT Inhibitor

[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects

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The only proposed difference is the salt counterion used in synthesis: arginine instead of acetate

Combined with the D+Q associated reduction in ventricle size as assessed by MRI, a surrogate measure of neurodegeneration, the data suggested that clearing senescent cells was beneficial for neuronal preservation