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19 Under oxidative stress, the glutathione (GSH) level in cardiomyocytes decreases by 6070%, and the levels of Gln, glutamate and -ketoglutarate (-KG) also decrease significantly, while the enzyme activity of GLS, which converts Gln to glutamate, is enhanced

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The Experiment: Pyxis Identifies Over 100 CHO Cell Metabolites in Under 15 Minutes To validate Pyxis in a bioprocessing setting, Matterworks partnered with Johnson & Johnson Innovative Medicine to profile CHO cell spent media and cell pellets collected daily over two 13-day, 10-L bioreactor runs