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Another approach proposed by the FDA is to reduce nicotine content in combustible cigarettes

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As pleural mesothelioma progresses, it can also cause other symptoms and complications such as difficulty swallowing, pain due to pressure on the nerves in the chest, pleural thickening, pleural effusion (fluid buildup in the chest cavity), which can compress the lungs and cause difficulties with breathing

Talikka M, Sierro N, Ivanov NV, et al