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Genetic Association of the Transsulfuration Pathway with NAFLD A study including 268 patients who underwent a liver biopsy during surgery found that single-nucleotide polymorphisms (SNPs) in the Glycine N-methyltransferase (GNMT) gene were associated with hepatic levels of the GNMT protein, while this was not the case for SNPs in the MAT1A gene and the MAT protein [128]