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For example, EC use by PWNS could explain why EC use is associated with worsening symptoms, while EC use by people who switched away from smoking could explain why EC use is also associated with symptom improvement

Oral Oncol, 45(4-5):351-355

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Thus, this work provided new insights about the strong relationship between smoke exposure and behavioural patterns, where the changes caused by smoke, such as inflammation and oxidative stress, could lead to anxiety and panic-related behaviours, independent of the influence of nicotine or other tobacco components

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