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Cell death is an essential hallmark of life, and ferroptosis is a specific form of cell death distinct from necrosis, apoptosis, or autophagy that is linked to certain physiological and pathological processes

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Results VRK2-deficient PC cells are vulnerable to GSH inhibition To investigate the impact of VRK2 on metabolic reprogramming, we treated VRK2-wild-type (VRK2-WT) and VRK2-knockout (VRK2-KO) CFPAC-1 cell lines with 281 metabolism compounds (Supplementary Table1)

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The rapid success of SGLT2 inhibitors reflects not only their strong mechanistic rationale but also broad applicability across HF phenotypes and the advantage of testing within large cardiovascular outcome trials originally designed for diabetes